N-(2-Aminoethyl)ethyleneurea → HCID 60204268, 화합물

HRID 507521

반응식

HRID 507521 반응식
[Br:1][C:2]1[S:6][C:5]([C:7]2[CH:12]=[CH:11][N:10]=[C:9](Cl)[N:8]=2)=[CH:4][CH:3]=1.[NH2:14][CH2:15][CH2:16][N:17]1[CH2:21][CH2:20][NH:19][C:18]1=[O:22]>C(O)(C)C>[Br:1][C:2]1[S:6][C:5]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH:14][CH2:15][CH2:16][N:17]3[CH2:21][CH2:20][NH:19][C:18]3=[O:22])[N:8]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 80480N-(2-Aminoethyl)ethyleneureaHCID 15141655HCID 15141655, 화합물

생성물 1

HCID 60204268HCID 60204268, 화합물수율 68%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A mixture of 4-(5-bromothiophen-2-yl)-2-chloropyrimidine (1.0 g, 3.63 mmol), 1-(2-aminoethyl)imidazolidin-2-one (0.47 g, 3.63 mmol) and triethylame (0.44 g, 4.36 mmol) in isopropanol (25 mL) was refluxed for 30 h. After cooling down to rt the precipitate was filtered and washed with methanol (5 mL) and dried to give the title compound as a yellow solid (0.9 g, 68%). MS (M+H)+ 368/370.

후처리

  1. temperaturewas refluxed for 30 h
  2. filtrationwas filtered
  3. washwashed with methanol (5 mL)
  4. customdried

출처 및 근거

ORD 기록
ord-177cb6d9dcaf40178917a7289810f389
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786132B2

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