Sodium Hydroxide → 7-Chloro-1-benzothiophene-2-carboxylic acid

HRID 507694노트

반응식

HRID 507694 반응식
[Cl:1][C:2]1[C:7]2[S:8][C:9]([C:11]([O:13]C)=[O:12])=[CH:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[C:7]2[S:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 22474203Methyl 7-chlorobenzo[b]thiophene-2-carboxylate

생성물 1

HCID 101982427-Chloro-1-benzothiophene-2-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Methyl 7-chlorobenzo[b]thiophene-2-carboxylate (3 g, 13 mmol) was dissolved is ethanol (15 mL) and treated 5 N sodium hydroxide (5 mL). The reaction was heated at reflux overnight. The volatiles were removed in vacuo and the aqueous residue was acidified to pH 2 using 5 N HCl. The resulting white solid was filtered off, washed well with water and dried in a vacuum oven at 60° C. Yield=2.6 g. MS (M−H)− 210.

후처리

  1. temperatureThe reaction was heated
  2. temperatureat reflux overnight
  3. customThe volatiles were removed in vacuo
  4. filtrationThe resulting white solid was filtered off
  5. washwashed well with water
  6. customdried in a vacuum oven at 60° C

출처 및 근거

ORD 기록
ord-fea189dc2932427e8c75b27d77b41223
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786132B2

반응 노트

불러오는 중…