Water → HCID 23157557, 화합물

HRID 507979노트

반응식

HRID 507979 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH2:11][CH2:12][C:13]2=[O:18].[BH4-].[Na+].O>O1CCCC1.CO>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH2:11][CH2:12][CH:13]2[OH:18]

참가 물질

6

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 23157344HCID 23157344, 화합물

생성물 1

HCID 23157557HCID 23157557, 화합물수율 76.3%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

4-(2,6-Dimethylphenyl)indan-1-one (2.00 g, 8.47 mmol) was dissolved in a mixture of tetrahydrofuran (20 mL) and methanol (10 mL), sodium borohydride (449 mg, 11.9 mmol) was added, and the mixture was stirred at room temperature for 2 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was dried, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (5%-60% ethyl acetate/hexane) to give the title compound (1.54 g, yield 76%) as a colorless oil.

후처리

  1. additionwas added
  2. extractionthe mixture was extracted with ethyl acetate
  3. customThe extract was dried
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was purified by silica gel column chromatography (5%-60% ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-d1f0e4165c3c47d79d26112fc162bcb8
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786165B2

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