Hydrochloric Acid → 3-Fluoro-4-nitrobenzyl alcohol

HRID 508376노트

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HRID 508376 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5](O)=[O:6].Cl>C1COCC1>[F:1][C:2]1[CH:3]=[C:4]([CH2:5][OH:6])[CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 2306533-Fluoro-4-nitrobenzoic acid

생성물 1

HCID 27746583-Fluoro-4-nitrobenzyl alcohol수율 97%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
0 °C

실험 절차

To a solution of 3-fluoro-4-nitrobenzoic acid (2.0 g, 10.8 mmol) in THF (50 ml) at 0° C. was added BH3.Me2S complex (2.215 ml, 22.15 mmol) drop-wise. The mixture was stirred at 0° C. for 3 h, and was then stirred at 65° C. for 18 h. To the cooled mixture was added ice (50 g), followed by 1 N aq. HCl (100 ml), and the resulting mixture was extracted with EtOAc (200 ml). The organic layer was dried over Na2SO4, filtered and concentrated in vacuo to provide the title compound as a white solid (1.79 g, 97%).

후처리

  1. stirringwas then stirred at 65° C. for 18 h
  2. extractionthe resulting mixture was extracted with EtOAc (200 ml)
  3. dry with materialThe organic layer was dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-9794bab93f224841acc2508a91c884a6
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09095590B2

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