Water → 2-Bromo-4,5-dimethoxybenzoic acid

HRID 508389

반응식

HRID 508389 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6]([OH:8])=[O:7].[Br:14]Br.O>Cl>[Br:14][C:9]1[CH:10]=[C:11]([O:12][CH3:13])[C:3]([O:2][CH3:1])=[CH:4][C:5]=1[C:6]([OH:8])=[O:7]

참가 물질

5

반응물 3

HCID 962WaterHCID 7121Veratric AcidHCID 24408Bromine

생성물 1

HCID 2229632-Bromo-4,5-dimethoxybenzoic acid수율 96.2%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

3,4-Dimethoxybenzoic acid (25.0 g) was suspended in concentrated hydrochloric acid (35%) (500 mL), and bromine (23.0 g, 1.05 equivalents) was added dropwise to the resultant suspension at 25° C. Subsequently, the resultant mixture was stirred for seven hours. Water (500 mL) was added to the mixture, and the mixture was stirred for one hour. Thereafter, the precipitated crystals were filtrated, and then dried under reduced pressure, to thereby produce crude crystals of 2-bromo-4,5-dimethoxybenzoic acid (34.47 g) (yield: 96.2%).

후처리

  1. filtrationThereafter, the precipitated crystals were filtrated
  2. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-ab2cb0c75bab4d10a547cd259bedac49
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096511B2

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