Sodium borohydride → HCID 22736932, 화합물

HRID 50855노트

반응식

HRID 50855 반응식
[BH4-].[Na+].[OH:3][C:4]1([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=2)[CH2:9][CH2:8][N:7]([CH2:10][C:11]([C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[NH:19][C:18](=[O:23])[CH2:17][CH2:16]3)=[O:12])[CH2:6][CH2:5]1>C(O)C>[OH:12][CH:11]([C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[NH:19][C:18](=[O:23])[CH2:17][CH2:16]2)[CH2:10][N:7]1[CH2:8][CH2:9][C:4]([OH:3])([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=2)[CH2:5][CH2:6]1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 227369406-{[4-Hydroxy-4-(3-methoxyphenyl)-1-piperidinyl]acetyl}-3,4-dihydroquinolin-2(1h)-one

생성물 1

HCID 22736932HCID 22736932, 화합물수율 69%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

To a stirred solution of sodium borohydride (1.15 g, 30.3 mmol) in ethanol (100 ml) was added suspension of 6-{[4-Hydroxy-4-(3-methoxyphenyl)-1-piperidinyl]acetyl}-3,4-dihydroquinolin-2(1H)-one (5.98 g, 15.2 mmol) in ethanol (40 ml) at 0° C. and the reaction mixture was stirred at room temperature overnight. The precipitate was filtered and added to methanol (20 ml). The precipitate was collected by filtration to afford the title compound (4.13 g, 69%) as a white solid.

후처리

  1. filtrationThe precipitate was filtered
  2. additionadded to methanol (20 ml)
  3. filtrationThe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-de7cfd67a4e444bfa6aef484216011e4
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713490B2

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