Hydrazine hydrate (1:1) → 2-(4-Morpholinyl)acetohydrazide

HRID 508681

반응식

HRID 508681 반응식
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([O:10]C)=O)[CH2:3][CH2:2]1.O.[NH2:13][NH2:14]>C(O)C>[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([NH:13][NH2:14])=[O:10])[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 1268178Methyl Morpholinoacetate

생성물 1

HCID 3516352-(4-Morpholinyl)acetohydrazide수율 92%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
95 °C

실험 절차

In a 25 mL, 3-neck round-bottom flask, methyl 2-morpholinoacetate (0.25 g, 1.0 eq.) was dissolved in ethanol (5 mL) at RT. Hydrazine hydrate (0.087 g, 1.1 eq.) was introduced dropwise at RT and the reaction mixture was refluxed at 95° C. for 20 h. The reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg) to afford the crude 2-morpholinoacetohydrazide (0.23 g) which was used without further purification in the following step.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg)

출처 및 근거

ORD 기록
ord-3b0a93b7c5fc45fb972dc6e5c9848663
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096543B2

연결된 노트

불러오는 중…