Methylhydrazine → N-methyl-2-morpholinoacetohydrazide

HRID 508686노트

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HRID 508686 반응식
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([O:10]C)=O)[CH2:3][CH2:2]1.[CH3:12][NH:13][NH2:14]>C(O)C>[CH3:12][N:13]([C:8](=[O:10])[CH2:7][N:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1)[NH2:14]

참가 물질

4

반응물 2

HCID 6061MethylhydrazineHCID 1268178Methyl Morpholinoacetate

생성물 1

HCID 86703007N-methyl-2-morpholinoacetohydrazide수율 49.6%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
95 °C

실험 절차

In a 25 mL, sealed tube, methyl 2-morpholinoacetate (0.5 g, 1.0 eq.) was dissolved in ethanol (5 mL) at RT. Methylhydrazine (0.16 g, 1.1 eq.) was introduced dropwise at RT and the reaction mixture was refluxed at 95° C. for 48 h. The reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg) to afford the crude N-methyl-2-morpholinoacetohydrazide (0.27 g) which was used without further purification in the following step.

후처리

  1. customIn a 25 mL, sealed tube
  2. concentrationThe reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg)

출처 및 근거

ORD 기록
ord-b3474f529fd14022bccf6ff838c738a6
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096543B2

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