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Hydrochloric Acid → (E)-1-(6-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride

HRID 50873
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HRID 50873 반응식
[CH:1]([C:9]1[NH:13][C:12]2[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=2[N:10]=1)=[CH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[N:20]=1.N1C=CC=CC=1N1C2C=CC=CC=2N=C1/C=C/C1C=CC=CC=1.Cl>CO>[ClH:18].[CH3:25][C:21]1[N:20]=[C:19]([N:13]2[C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[N:10]=[C:9]2/[CH:1]=[CH:2]/[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:24]=[CH:23][CH:22]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 876016-Chloro-2-picolineHCID 2429652-(2-Phenylethenyl)-1h-benzimidazoleHCID 9796241(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole

생성물 1

HCID 22736649(E)-1-(6-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride

시약·촉매·용매 1

HCID 887
Methanol
용매

실험 절차

Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 2-Chloro-6-methylpyridine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from ethyl acetate/n-hexane to give the titled compound. MW: 347.85; mp: 216.0-217.0° C.; 1H-NMR (DMSO-d6) δ: 8.20 (1H, br s), 8.10 (1 H, t, J=7.7 Hz), 7.87 (1H, d, J=7.7 Hz), 7.71-7.44 (10H, m), 7.22 (1H, d, J=16.1 Hz), 2.63 (3H, s).

후처리

  1. concentrationconcentrated to dryness
  2. customThe residue was recrystallized from ethyl acetate/n-hexane

출처 및 근거

ORD 기록
ord-3a8120cb18b04255baa1d1cdaaa70be9
출처 데이터셋
uspto-grants-2004_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06713482B2

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