Hydrochloric Acid → (4-Chloro-3-nitrobenzyl)amine hydrochloride

HRID 508779

반응식

HRID 508779 반응식
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][NH:7]C(=O)C(F)(F)F)=[CH:4][C:3]=1[N+:16]([O-:18])=[O:17].Cl>CO>[ClH:1].[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][NH2:7])=[CH:4][C:3]=1[N+:16]([O-:18])=[O:17]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 19879857N-(4-chloro-3-nitrobenzyl)-2,2,2-trifluoroacetamide

생성물 1

HCID 18796739(4-Chloro-3-nitrobenzyl)amine hydrochloride수율 221.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of N-(4-chloro-3-nitrobenzyl)-2,2,2-trifluoroacetamide (0.800 g) in methanol (20 mL) was added conc. HCl (2.0 ml). The reaction mass was refluxed for 18 h. Excess solvent was removed under vacuum to afford 0.700 g of desired product. 1H NMR (300 MHz, DMSO d6): δ 7.18 (s, 1H), 7.35 (s, 1H), 7.52 (s, 1H), 7.86 (s, 2H), 8.28 (s, 1H), 8.72 (br s, 2H).

후처리

  1. temperatureThe reaction mass was refluxed for 18 h
  2. customExcess solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-34c81e3d4f8c47948ae2c6a9421f22d6
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096545B2

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