Hydrochloric Acid → Methyl 2-(benzylamino)acetate hydrochloride

HRID 509183

반응식

HRID 509183 반응식
[CH2:1]([NH:8][CH2:9][C:10]([OH:12])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:13].[CH3:14]O>O1CCOCC1>[ClH:13].[CH2:1]([NH:8][CH2:9][C:10]([O:12][CH3:14])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 869652-(Benzylamino)acetic acid

생성물 1

HCID 24192994Methyl 2-(benzylamino)acetate hydrochloride수율 99%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a N-benzyl glycine 26 (500 mg, 3.0 mmol) in MeOH (6 mL) was added 4M solution of HCl in dioxane (4 mL) and stirred overnight. The reaction mixture was concentrated to afford compound 27 (649 mg, 99%) as a white solid. The crude compound was carried forward without further purification. LRMS (ESI): (calc) 179.2 (found) 180.1 (MH)+.

후처리

  1. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-38f9f87398bf4542975c2b2409b64c8e
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096565B2

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