4-Fluoro-2-nitroaniline → (E)-5-Fluoro-1-(2-pyridyl)-2-styryl-1H-benzimidazole

HRID 50920

반응식

HRID 50920 반응식
[F:1]C1C=CC(N)=C([N+]([O-])=O)C=1.[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N:18]1[C:22]2[CH:23]=[CH:24][C:25](C(F)(F)F)=[CH:26][C:21]=2[N:20]=[C:19]1/[CH:31]=[CH:32]/[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[F:1][C:25]1[CH:24]=[CH:23][C:22]2[N:18]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][N:12]=3)[C:19](/[CH:31]=[CH:32]/[C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[N:20][C:21]=2[CH:26]=1

참가 물질

3

반응물 2

HCID 677694-Fluoro-2-nitroanilineHCID 22736704(E)-1-(2-pyridyl)-2-styryl-5-trifluoromethyl-1H-benzimidazole

생성물 1

HCID 22736771(E)-5-Fluoro-1-(2-pyridyl)-2-styryl-1H-benzimidazole

실험 절차

The titled compound was prepared from 4-fluoro-2-nitroaniline according to the preparation of (E)-1-(2-pyridyl)-2-styryl-5-trifluoromethyl-1H-benzimidazole (Example 57). MW: 315.35; mp: 134.0-135.0° C.; 1H-NMR (CDCl3) δ: 8.78 (1H, ddd, J=4.8, 1.8, 1.1 Hz), 8.04-7.96 (1H, m), 8.00 (1H, d, J=15.8 Hz), 7.54-7.45 (5H, m), 7.42-7.30 (4H, m), 7.10 (1H, d, J=16.1 Hz), 7.01 (1H, td, J=9.2, 2.6 Hz).

출처 및 근거

ORD 기록
ord-46e25139ab334712ae031c4c25160f25
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713482B2

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