4-(Benzylamino)-1-methylcyclohexanol → Trans-4-amino-1-methyl-cyclohexanol

HRID 509292

반응식

HRID 509292 반응식
C([NH:8][CH:9]1[CH2:14][CH2:13][C:12]([CH3:16])([OH:15])[CH2:11][CH2:10]1)C1C=CC=CC=1>CCO.[Pd]>[NH2:8][CH:9]1[CH2:14][CH2:13][C:12]([CH3:16])([OH:15])[CH2:11][CH2:10]1

참가 물질

4

반응물 1

HCID 674652054-(Benzylamino)-1-methylcyclohexanol

생성물 1

HCID 18331273Trans-4-amino-1-methyl-cyclohexanol수율 83%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

4-(Benzylamino)-1-methylcyclohexanol (335 mg, 1.53 mmol) was dissolved in EtOH (7.95 ml), followed by addition of Pd (10 wt % on activated carbon, 35 mg), and then the resulting liquid was stirred at room temperature under hydrogen stream for 31 hours. The resulting reaction liquid was filtered, concentrated under reduced pressure, and dried under vacuum, to obtain 164 mg of white solid (83%).

후처리

  1. customThe resulting reaction liquid
  2. filtrationwas filtered
  3. concentrationconcentrated under reduced pressure
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-791d899581944fa1a13752746fd44160
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096571B2

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