6-Chloro-2-nitropyridin-3-amine → 6-Chloropyridine-2,3-diamine
반응식
[Cl:1][C:2]1[N:7]=[C:6]([N+:8]([O-])=O)[C:5]([NH2:11])=[CH:4][CH:3]=1>[Ni].CO>[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([NH2:11])=[CH:4][CH:3]=1참가 물질
4
실험 절차
A mixture of 6-chloro-2-nitropyridin-3-amine (E-23) (8.8 g, 51 mmol, 1.0 eq) and Raney nickel (0.88 g) in Methanol (100 mL) was stirred under hydrogen at RT for 24 h, then filtered and the filtrate was concentrated in vacuo to afford the desired product 6-chloropyridine-2,3-diamine (E-24) (7 g, 95.6% yield) as a pale solid. ESI-MS m/z: 144.05[M+H]+.
후처리
- filtrationfiltered
- concentrationthe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-996bbfa716ca4ce1b163b10fbae208df
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09096590B2
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