Methanesulfonyl chloride → 3-Methoxybenzyl methanesulfonate

반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][OH:7].[CH3:11][S:12](Cl)(=[O:14])=[O:13]>>[CH3:11][S:12]([O:7][CH2:6][C:5]1[CH:8]=[CH:9][CH:10]=[C:3]([O:2][CH3:1])[CH:4]=1)(=[O:14])=[O:13]

참가 물질

반응물 2

HCID 31297Methanesulfonyl chloride

HCID 814373-Methoxybenzyl alcohol

생성물 1

HCID 154385793-Methoxybenzyl methanesulfonate

실험 절차

The title compound was prepared by following the general procedure of Example 43 for mesylation as a colorless oil (292 mg, 93%) from 3-methoxybenzyl alcohol (200 mg, 1.45 mmol) and methanesulfonyl chloride (249 mg, 2.17 mmol). 1H NMR (CDCl3, 300 MHz) δ2.92 (s, 3H), 3.83 (s, 3H), 5.22 (s, 2H), 6.90-7.03 (m, 3H), 7.32 (t, 1H, J=7.7 Hz) ppm.

출처 및 근거

ORD 기록: ord-4aae77ffae474e92b9425286f9f3309b
출처 데이터셋: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06713471B1

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