Hydrochloric Acid → HCID 136364529, 화합물

HRID 510053노트

반응식

HRID 510053 반응식
[Si]([O:8][C:9]1[C:10]([NH2:33])=[N:11][C:12]([C:16]2[C:24]3[C:19](=[N:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[F:32])[N:17]=2)=[N:13][C:14]=1[NH2:15])(C(C)(C)C)(C)C.Cl>O1CCCC1>[NH2:33][C:10]1[C:9]([OH:8])=[C:14]([NH2:15])[N:13]=[C:12]([C:16]2[C:24]3[C:19](=[N:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[F:32])[N:17]=2)[N:11]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 66614198HCID 66614198, 화합물

생성물 1

HCID 136364529HCID 136364529, 화합물수율 47.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

447 mg (0.96 mmol) of the compound obtained in example 57A were initially charged in 10 ml of tetrahydrofuran, and 6 ml of 3M hydrochloric acid were added. The next day, the mixture was concentrated to dryness and the residue was stirred with acetonitrile, water and dimethylformamide The precipitate was filtered off and washed with acetonitrile. 159 mg of the title compound were obtained (92% purity; 43% of theory).

후처리

  1. concentrationThe next day, the mixture was concentrated to dryness
  2. filtrationwas filtered off
  3. washwashed with acetonitrile

출처 및 근거

ORD 기록
ord-2121db27b8f94743abe1dbe622b30754
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096592B2

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