1-Bromo-3-chloropropane → 1-(3-Chloropropyl)-6-fluoroindole
반응식
Br[CH2:2][CH2:3][CH2:4][Cl:5].[F:6][C:7]1[CH:15]=[C:14]2[C:10]([CH:11]=[CH:12][NH:13]2)=[CH:9][CH:8]=1.[OH-].[K+]>CN(C=O)C>[Cl:5][CH2:4][CH2:3][CH2:2][N:13]1[C:14]2[C:10](=[CH:9][CH:8]=[C:7]([F:6])[CH:15]=2)[CH:11]=[CH:12]1참가 물질
5
반응 조건
- 온도
- 20 °C
실험 절차
To a solution of 1-bromo-3-chloropropane (700 mg, 4.44 mmol) in DMF (2.4 mL) was added 6-fluoroindole (200 mg, 1.48 mmol) and powder KOH (92 mg, 1.63 mmol) at 20° C. The reaction mixture was stirred for 15 h at 20° C. then quenched by addition of H2O and extracted with Et2O. The combined organic solution was successively washed with brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was chromatographed to give 1-(3-chloropropyl)-6-fluoroindole (190 mg, 66%) as a colorless oil.
후처리
- customthen quenched by addition of H2O
- extractionextracted with Et2O
- washThe combined organic solution was successively washed with brine
- dry with materialdried over MgSO4
- filtrationfiltered
- concentrationconcentrated in vacuo
- customThe residue was chromatographed
출처 및 근거
- ORD 기록
- ord-f8f8abdedbe44766b4744b3242669eaa
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06713471B1
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