Purine → 9-(3-Chloropropyl)purine

HRID 51017

반응식

HRID 51017 반응식
[N:1]1[CH:9]=[C:8]2[C:4]([N:5]=[CH:6][NH:7]2)=[N:3][CH:2]=1.Br[CH2:11][CH2:12][CH2:13][Cl:14].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Cl:14][CH2:13][CH2:12][CH2:11][N:5]1[CH:6]=[N:7][C:8]2[C:4]1=[N:3][CH:2]=[N:1][CH:9]=2.[Cl:14][CH2:13][CH2:12][CH2:11][N:7]1[C:8]2[C:4](=[N:3][CH:2]=[N:1][CH:9]=2)[N:5]=[CH:6]1

참가 물질

6

반응물 3

HCID 1044PurineHCID 80061-Bromo-3-chloropropaneHCID 11430Potassium Carbonate

생성물 2

HCID 227156719-(3-Chloropropyl)purine수율 68%HCID 22735881HCID 22735881, 화합물수율 23%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
20 °C

실험 절차

To a solution of purine (360 mg, 3.00 mmol) and 1-bromo-3-chloropropane (1.42 g, 9.0 mmol) in DMF (10 mL) was added K2CO3 (622 mg, 4.5 mmol) at 20° C. The reaction mixture was stirred for 24 h at 20° C. and filtered. The filtrate was concentrated in vacuo and the residue was chromatographed to give 9-(3-chloropropyl)purine (400 mg, 68%) and 7-(3-chloropropyl)purine (136 mg, 23%) as colorless oils.

후처리

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo
  3. customthe residue was chromatographed

출처 및 근거

ORD 기록
ord-470d3512ab9e436aa10bae0f745433e9
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713471B1

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