1-(5-Chloro-2-methoxy-4-methyl-3-nitrophenyl)ethanone → HCID 86666790, 화합물

HRID 510859노트

반응식

HRID 510859 반응식
[Cl:1][C:2]1[C:3]([CH3:16])=[C:4]([N+:13]([O-])=O)[C:5]([O:11][CH3:12])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1.[H][H]>CO.[Pt]>[NH2:13][C:4]1[C:5]([O:11][CH3:12])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=[C:2]([Cl:1])[C:3]=1[CH3:16]

참가 물질

5

반응물 2

HCID 27576391-(5-Chloro-2-methoxy-4-methyl-3-nitrophenyl)ethanoneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 86666790HCID 86666790, 화합물

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 887Methanol용매

실험 절차

1-(5-Chloro-2-methoxy-4-methyl-3-nitrophenyl)ethanone (5.0 g, 20 mmol) was hydrogenated in 100 mL of methanol in the presence of 0.5 g of 10% Pt/C, under a balloon pressure of hydrogen overnight. The catalyst was filtered off and the filtrate was concentrated. The residue was dissolved in dichloromethane and dried over sodium sulfate and then evaporated to dryness. The crude product was used directly in next step (4.4 g, 100%). LCMS calculated for C10H13ClNO2 (M+H)+: m/z=214.1. found: 214.1.

후처리

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated
  3. dissolutionThe residue was dissolved in dichloromethane
  4. dry with materialdried over sodium sulfate
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-7faae9379b584c049d8a8ac3a14c5080
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096600B2

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