2-Tert-Butylphenol → (2R)-7-(3-(2-Chloro-4-tert-butylphenoxy)propoxy)-2-methylchromane-2-carboxylic Acid
반응식
[C:1](C1C=CC=CC=1O)(C)(C)C.[Cl:12][C:13]1[CH:37]=[C:36]([CH:38]2[CH2:43]CCC[CH2:39]2)[CH:35]=[CH:34][C:14]=1[O:15][CH2:16][CH2:17][CH2:18][O:19][C:20]1[CH:29]=[C:28]2[C:23]([CH2:24][CH2:25][C@:26]([CH3:33])([C:30]([OH:32])=[O:31])[O:27]2)=[CH:22][CH:21]=1>>[Cl:12][C:13]1[CH:37]=[C:36]([C:38]([CH3:43])([CH3:1])[CH3:39])[CH:35]=[CH:34][C:14]=1[O:15][CH2:16][CH2:17][CH2:18][O:19][C:20]1[CH:29]=[C:28]2[C:23]([CH2:24][CH2:25][C@:26]([CH3:33])([C:30]([OH:32])=[O:31])[O:27]2)=[CH:22][CH:21]=1참가 물질
3
실험 절차
The title compound was prepared following the procedures described in Example 5, Step B-E employing tert-butylphenol instead of 4-(2,2,2-trifluoroethoxy)phenol, and (2R)-methyl 2-methyl-7-hydroxychromane-2-carboxylate (Example 23, Step A) instead of ethyl 2-ethyl-7-hydroxychromane-2-carboxylate.
출처 및 근거
- ORD 기록
- ord-3448a21a844243a6886e07a4cdd6700f
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06713508B2
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