N-Iodosuccinimide → 1-(5-Chloro-4-fluoro-2-hydroxy-3-iodophenyl)ethanone
반응식
[Cl:1][C:2]1[C:3]([F:12])=[CH:4][C:5]([OH:11])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1.[I:13]N1C(=O)CCC1=O>C(O)(=O)C>[Cl:1][C:2]1[C:3]([F:12])=[C:4]([I:13])[C:5]([OH:11])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1참가 물질
4
반응 조건
- 온도
- 70 °C
실험 절차
A solution of 1-(5-chloro-4-fluoro-2-hydroxyphenyl)ethanone (23.8 g, 126 mmol) in acetic acid (100 mL) was treated with N-iodosuccinimide (34.1 g, 151 mmol) and stirred at 70° C. for 2 hours. The reaction mixture was concentrated, diluted with EtOAc and quenched with sat. NaHCO3 solution. The organic layer was separated, washed with water, dried over MgSO4 and concentrated under reduced pressure to give the desired product to be used in the next step without further purification.
후처리
- concentrationThe reaction mixture was concentrated
- additiondiluted with EtOAc
- customquenched with sat. NaHCO3 solution
- customThe organic layer was separated
- washwashed with water
- dry with materialdried over MgSO4
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-8fcb8817adc1452aba252d85dc052234
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09096600B2
반응 노트
불러오는 중…