Lithium Hydroxide → 3-[1-(4-Tert-butyl-phenyl)-piperidin-4-yl]-propionic acid lithium salt

HRID 511184노트

반응식

HRID 511184 반응식
C[O:2][C:3](=[O:22])[CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:14][CH:13]=2)[CH2:8][CH2:7]1.[OH-].[Li+:24].O1CCCC1>O.C(#N)C>[Li+:24].[C:18]([C:15]1[CH:14]=[CH:13][C:12]([N:9]2[CH2:10][CH2:11][CH:6]([CH2:5][CH2:4][C:3]([O-:22])=[O:2])[CH2:7][CH2:8]2)=[CH:17][CH:16]=1)([CH3:21])([CH3:19])[CH3:20]

참가 물질

6

반응물 3

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 585763793-[1-(4-Tert-butyl-phenyl)-piperidin-4-yl]-propionic acid methyl ester

생성물 1

HCID 585759763-[1-(4-Tert-butyl-phenyl)-piperidin-4-yl]-propionic acid lithium salt

시약·촉매·용매 2

HCID 962Water용매HCID 6342Acetonitrile용매

실험 절차

To 3-[1-(4-tert-butyl-phenyl)-piperidin-4-yl]-propionic acid methyl ester (295 mg; 0.97 mmol, prepared in accordance with Example 145) is added lithium hydroxide (72 mg; 3.00 mmol) dissolved in water (6.5 mL). After dilution with tetrahydrofuran (10 mL) the reaction mixture is stirred for 2-4 hours. The mixture is then diluted with acetonitrile until a precipitate is formed. The solid is collected by filtration and dried under high vacuum to deliver the desired product (468 mg) which is used in the next step without further purification.

후처리

  1. customis formed
  2. filtrationThe solid is collected by filtration
  3. customdried under high vacuum
  4. customis used in the next step without further purification

출처 및 근거

ORD 기록
ord-755d8b18423240c894b081756c8a8013
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096524B2

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