Trifluoroacetic acid → 3-Mercapto-2-pyrrolidinone trifluoromethanesulfonate

HRID 5118

반응식

HRID 5118 반응식
FC(F)(F)C(O)=O.[F:8][C:9]([F:15])([F:14])[S:10]([OH:13])(=[O:12])=[O:11].COC1C=CC(C[S:23][CH:24]2[CH2:28][CH2:27][NH:26][C:25]2=[O:29])=CC=1>C1(OC)C=CC=CC=1>[F:8][C:9]([F:15])([F:14])[S:10]([OH:13])(=[O:12])=[O:11].[SH:23][CH:24]1[CH2:28][CH2:27][NH:26][C:25]1=[O:29]

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 62406Trifluoromethanesulfonic acidHCID 102432413-(4-Methoxybenzylthio)pyrrolidin-2-one

생성물 1

HCID 197972633-Mercapto-2-pyrrolidinone trifluoromethanesulfonate

시약·촉매·용매 1

HCID 7519Anisole용매

실험 절차

20 ml of trifluoroacetic acid and 0.41 ml of trifluoromethanesulfonic acid were added, whilst ice-cooling, to a solution of 949 mg of 3-(4-methoxybenzylthio)pyrrolidin-2-one in 4 ml of anisole, and then the mixture was stirred at room temperature for 30 minutes. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure to leave a residue, which was purified by column chromatography through silica gel, eluted with a 10:1 by volume mixture of ethyl acetate and methanol, to give 728 mg of the title compound as an oil.

후처리

  1. concentrationAt the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure
  2. customto leave a residue, which
  3. customwas purified by column chromatography through silica gel
  4. washeluted with a 10:1 by volume mixture of ethyl acetate and methanol

출처 및 근거

ORD 기록
ord-715795a169ab49eca88ae924fb7a34b7
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05242914

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