Triphenylphosphine → 4-Bromobenzylamine
반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([CH2:6][N:7]=[N+]=[N-])=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>CO>[Br:1][C:2]1[CH:11]=[CH:10][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1참가 물질
4
실험 절차
To a stirred solution of azide 55 (0.75 g, 3.54 mmol) in anhydrous methanol (10 mL) was added triphenylphosphine (1.39 g, 5.31 mmol) and the mixture was heated under reflux for 1.5 hours. The reaction mixture was cooled to room temperature and the solvent was removed under reduced pressure. The residue was purified by flash column chromatography on silica gel (acetone-hexane) to yield product 56 in 63% yield (0.41 g).
후처리
- temperaturethe mixture was heated
- temperatureunder reflux for 1.5 hours
- customthe solvent was removed under reduced pressure
- customThe residue was purified by flash column chromatography on silica gel (acetone-hexane)
출처 및 근거
- ORD 기록
- ord-64ec4365084a4e599d116e72968b65f5
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09102622B2
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