Sodium Hydroxide → HCID 89545385, 화합물

HRID 512123노트

반응식

HRID 512123 반응식
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([CH:21]=[CH:22][CH:23]=1)[CH2:8][N:9]1[C:18]2[CH2:17][CH2:16][CH2:15][CH2:14][C:13]=2[C:12](=[O:19])[NH:11][C:10]1=[O:20])=[O:4].[OH-].[Na+]>O.CO>[C:3]([C:5]1[CH:6]=[C:7]([CH:21]=[CH:22][CH:23]=1)[CH2:8][N:9]1[C:18]2[CH2:17][CH2:16][CH2:15][CH2:14][C:13]=2[C:12](=[O:19])[NH:11][C:10]1=[O:20])([OH:4])=[O:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 895453961-(3-methoxycarbonylbenzyl)-5,6,7,8-tetrahydroquinazoline-2,4(1H,3H)-dione

생성물 1

HCID 89545385HCID 89545385, 화합물수율 82.1%

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

실험 절차

A solution of 1-(3-methoxycarbonylbenzyl)-5,6,7,8-tetrahydroquinazoline-2,4(1H,3H)-dione (2.3 g, 7.3 mmol) and NaOH (0.59 g, 14.7 mmol) in water-methanol (40 mL and 40 mL) was refluxed for 4 h. After the removal of methanol, the solution was adjusted to pH=2-3 by 3N hydrochloric acid (a.q). The mixture was filtered and the solid was washed by water, and dried to give the title compound (1.8 g, 82% yield) as yellow solid. MS: m/z 301.3 [M+H]+.

후처리

  1. customAfter the removal of methanol
  2. filtrationThe mixture was filtered
  3. washthe solid was washed by water
  4. customdried

출처 및 근거

ORD 기록
ord-7881f242a35046608e2de4048027de4d
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102631B2

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