Ammonia → (2-(2-Methylpyrimidin-5-yl)tetrahydrofuran-2-yl)methanamine

HRID 512208노트

반응식

HRID 512208 반응식
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2([C:13]#[N:14])[CH2:12][CH2:11][CH2:10][O:9]2)=[CH:4][N:3]=1.N>CO.[Ni]>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2([CH2:13][NH2:14])[CH2:12][CH2:11][CH2:10][O:9]2)=[CH:4][N:3]=1

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 867162372-(2-Methylpyrimidin-5-yl)tetrahydrofuran-2-carbonitrile

생성물 1

HCID 86716238(2-(2-Methylpyrimidin-5-yl)tetrahydrofuran-2-yl)methanamine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매2회

실험 절차

2-(2-Methylpyrimidin-5-yl)tetrahydrofuran-2-carbonitrile (18 mg, 0.095 mmol) was dissolved in MeOH(5 ml) and 7M NH3 in MeOH (1 ml). Argon was bubbled through the solution. Raney Nickel (6 mg, 0.1 mmol) was added and the flask was fitted with a H2-balloon and stirred at room temperature for 1½ hour. Reaction was filtred through a plug of celite and concentrated in vacuo. Used for next step without further purification. LC-MS (m/z) 194.0 (MH+), tR (minutes, Method D)=0.17.

후처리

  1. customArgon was bubbled through the solution
  2. customthe flask was fitted with a H2-balloon
  3. customReaction
  4. concentrationconcentrated in vacuo
  5. customUsed for next step without further purification

출처 및 근거

ORD 기록
ord-6221c7e565f74f5e8f6930fb652ed982
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102591B2

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