2-Amino-4-chlorophenol → HCID 178527795, 화합물

HRID 512442노트

반응식

HRID 512442 반응식
O(CC)[C:2]([S-])=[S:3].[K+].[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([NH2:16])[CH:10]=1>C(O)C>[Cl:8][C:9]1[CH:14]=[CH:13][C:12]2[O:15][C:2]([SH:3])=[N:16][C:11]=2[CH:10]=1

참가 물질

4

반응물 2

HCID 72652-Amino-4-chlorophenolHCID 2735045Potassium ethylxanthate

생성물 1

HCID 178527795HCID 178527795, 화합물수율 99.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of potassium ethyl xanthate (13.4 g, 84.0 mmol) and 4-chloro-2-aminophenol (10 g, 69.6 mmol) was dissolved in absolute ethanol (200 mL). The mixture was stirred under reflux overnight. After cooling, the solvent was evaporated under reduced pressure, the residue was dissolved in water (200 mL) and treated with HOAc to adjust pH to 5. A solid formed, which was filtered and dried to afford 5-chloro-2-mercaptobenzoxazole (12.8 g, yield 99.1%).

후처리

  1. temperatureunder reflux overnight
  2. temperatureAfter cooling
  3. customthe solvent was evaporated under reduced pressure
  4. dissolutionthe residue was dissolved in water (200 mL)
  5. additiontreated with HOAc
  6. customA solid formed
  7. filtrationwhich was filtered
  8. customdried

출처 및 근거

ORD 기록
ord-333a50b1313d4f728f291bcb92d393b9
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102636B2

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