Water → 1-Butoxy-4,4,5,5-tetrafluoropent-1-en-3-one

HRID 512467노트

반응식

HRID 512467 반응식
[CH:1]([F:9])([F:8])[C:2]([F:7])([F:6])[C:3](Cl)=[O:4].N1C=CC=CC=1.[CH:16]([O:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH2:17].O>ClCCl>[CH2:19]([O:18][CH:16]=[CH:17][C:3](=[O:4])[C:2]([F:7])([F:6])[CH:1]([F:9])[F:8])[CH2:20][CH2:21][CH3:22]

참가 물질

6

반응물 4

HCID 962WaterHCID 1049PyridineHCID 8108Butyl vinyl etherHCID 27767442,2,3,3-Tetrafluoropropanoyl chloride

생성물 1

HCID 911638691-Butoxy-4,4,5,5-tetrafluoropent-1-en-3-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

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온도
0 °C

실험 절차

With stirring and at 0° C., 25.0 g (152 mmol) of 3H-tetrafluoropropionyl chloride—dissolved in 20 ml dichloromethane—were added to a mixture of 14.4 g (182 mmol) of pyridine and 15.2 g (152 mmol) of butyl vinyl ether in 250 ml of dichloromethane. After the addition, stirring was continued at room temperature for another 15 h. 250 ml of water were then added to the mixture, and the organic phase was separated off, dried and concentrated. This gave 12.5 g (36% of theory) of a yellowish oil.

후처리

  1. additionAfter the addition
  2. stirringstirring
  3. customthe organic phase was separated off
  4. customdried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5e56fafd7a5f45a6890f10a5dfa365be
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102623B2

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