Pyridine → 1-Butoxy-4-chloro-4,5,5,5-tetrafluoropent-1-en-3-one

HRID 512480노트

반응식

HRID 512480 반응식
[Cl:1][C:2]([F:10])([C:6]([F:9])([F:8])[F:7])[C:3](Cl)=[O:4].N1C=CC=CC=1.[CH:17]([O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH2:18]>ClCCl>[CH2:20]([O:19][CH:17]=[CH:18][C:3](=[O:4])[C:2]([Cl:1])([F:10])[C:6]([F:9])([F:8])[F:7])[CH2:21][CH2:22][CH3:23]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 8108Butyl vinyl etherHCID 27824982-Chloro-2,3,3,3-tetrafluoropropanoyl chloride

생성물 1

HCID 866240961-Butoxy-4-chloro-4,5,5,5-tetrafluoropent-1-en-3-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
0 °C

실험 절차

With stirring and at 0° C., 9.59 g (48.2 mmol) of 2-chlorotetrafluoropropionyl chloride were added dropwise to a mixture of 4.19 g (50.0 mmol) of pyridine and 4.83 g (48.2 mmol) of butyl vinyl ether in 75 ml of dichloromethane. After the addition, stirring was continued at room temperature for another 15 h. The mixture was then washed with 1N hydrochloric acid and 2×100 ml of water, and the organic phase was separated off, dried and concentrated. This gave 6.33 g (50% of theory) of a brown oil.

후처리

  1. additionAfter the addition
  2. stirringstirring
  3. washThe mixture was then washed with 1N hydrochloric acid and 2×100 ml of water
  4. customthe organic phase was separated off
  5. customdried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4ad6f0766f9e4ce5bc41e5dca8b88e96
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102623B2

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