2-Amino-2-cyanoacetamide → 5-Amino-2-(quinolin-6-ylamino)thiazole-4-carboxamide

HRID 512539

반응식

HRID 512539 반응식
[N:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][CH:8]=[CH:7]2)=[C:2]=[S:3].[NH2:14][CH:15]([C:19]#[N:20])[C:16]([NH2:18])=[O:17]>CCOC(C)=O>[NH2:20][C:19]1[S:3][C:2]([NH:1][C:4]2[CH:5]=[C:6]3[C:11](=[CH:12][CH:13]=2)[N:10]=[CH:9][CH:8]=[CH:7]3)=[N:14][C:15]=1[C:16]([NH2:18])=[O:17]

참가 물질

4

반응물 2

HCID 983412-Amino-2-cyanoacetamideHCID 137184226-Isothiocyanatoquinoline

생성물 1

HCID 867033765-Amino-2-(quinolin-6-ylamino)thiazole-4-carboxamide수율 65.4%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 6-isothiocyanatoquinoline (0.50 g, 2.7 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the residue was purified by silica gel column chromatography eluted with 2% MeOH in DCM to give 0.50 g (65% yield) of the titled compound.

후처리

  1. temperaturewas refluxed for 90 min
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customthe residue was purified by silica gel column chromatography
  4. washeluted with 2% MeOH in DCM

출처 및 근거

ORD 기록
ord-c7a2e6ea4fa742208557da471a08eaa9
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102637B2

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