2-Amino-2-cyanoacetamide → 5-Amino-2-(quinolin-6-ylamino)thiazole-4-carboxamide
반응식
[N:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][CH:8]=[CH:7]2)=[C:2]=[S:3].[NH2:14][CH:15]([C:19]#[N:20])[C:16]([NH2:18])=[O:17]>CCOC(C)=O>[NH2:20][C:19]1[S:3][C:2]([NH:1][C:4]2[CH:5]=[C:6]3[C:11](=[CH:12][CH:13]=2)[N:10]=[CH:9][CH:8]=[CH:7]3)=[N:14][C:15]=1[C:16]([NH2:18])=[O:17]참가 물질
4
실험 절차
A mixture of 6-isothiocyanatoquinoline (0.50 g, 2.7 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the residue was purified by silica gel column chromatography eluted with 2% MeOH in DCM to give 0.50 g (65% yield) of the titled compound.
후처리
- temperaturewas refluxed for 90 min
- concentrationThe reaction mixture was concentrated in vacuo
- customthe residue was purified by silica gel column chromatography
- washeluted with 2% MeOH in DCM
출처 및 근거
- ORD 기록
- ord-c7a2e6ea4fa742208557da471a08eaa9
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09102637B2
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