Benzyl Chloride → Methyl 2-(benzyloxy)propanoate

HRID 512810

반응식

HRID 512810 반응식
[C:1]([O:6][CH3:7])(=[O:5])[CH:2]([CH3:4])[OH:3].[CH2:8](Cl)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.CC(C)([O-])C.[Na+]>CN(C)C=O>[CH2:8]([O:3][CH:2]([CH3:4])[C:1]([O:6][CH3:7])=[O:5])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

5

반응물 3

HCID 7503Benzyl ChlorideHCID 11040Methyl LactateHCID 23676156Sodium t-butoxide

생성물 1

HCID 561764Methyl 2-(benzyloxy)propanoate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
30 °C

실험 절차

To a pre-cooled solution of racemic methyl lactate (200 g) in dimethyl formamide (400 ml) at 0-10° C., added benzyl chloride (218.8 g). Sodium tertiary butoxide (224.6 g) was added to the reaction mixture at 0-10° C. and stirred for 6 hours at 25-35° C. After completion of the reaction, the reaction mixture was quenched with water and extracted with toluene. The toluene layer was washed with water followed by 10% sodium chloride solution. The obtained toluene layer containing title compound was taken to next step.

후처리

  1. customAfter completion of the reaction
  2. customthe reaction mixture was quenched with water
  3. extractionextracted with toluene
  4. washThe toluene layer was washed with water
  5. additionThe obtained toluene layer containing title compound

출처 및 근거

ORD 기록
ord-a26405a450844edfbca5095bd1d67402
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102664B2

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