Sodium Hydroxide → 2-(4-fluorophenylthio)-N-cyclohexyl-N-phenylacetamide

HRID 51292

반응식

HRID 51292 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.[OH-].[Na+].Cl[CH2:12][C:13]([N:15]([CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:14]>O1CCCC1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:12][C:13]([N:15]([CH:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:14])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 677894-FluorothiophenolHCID 27949162-chloro-N-cyclohexyl-N-phenylacetamide

생성물 1

HCID 222511482-(4-fluorophenylthio)-N-cyclohexyl-N-phenylacetamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of 4-fluorothiophenol (0.13 mL, 1.2 mmol) in tetrahydrofuran (4 ml) was added aqueous 15% sodium hydroxide. 2-Chloro-N-cyclohexyl-N-phenylacetamide (320 mg, 1.3 mmol) was added, and the solution was stirred at room temperature for 16 hours. The solvent was removed under reduced pressure, and the residue purified on a preparatory plate using 20% ethyl acetate/hexanes to furnish 2-(4-fluorophenylthio)-N-cyclohexyl-N-phenylacetamide as a white solid. (M+1)=343.9

후처리

  1. customThe solvent was removed under reduced pressure
  2. customthe residue purified on a preparatory plate

출처 및 근거

ORD 기록
ord-4ea92079631e47d4bb3b62aa87db6404
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713650B2

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