Hydrochloric Acid → 4-(4-Methylpiperazin-1-yl)-2-nitrobenzoic acid hydrochloride

HRID 512995노트

반응식

HRID 512995 반응식
C([O:5][C:6](=[O:23])[C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]2)=[CH:9][C:8]=1[N+:20]([O-:22])=[O:21])(C)(C)C.[ClH:24]>O1CCOCC1>[ClH:24].[CH3:19][N:16]1[CH2:17][CH2:18][N:13]([C:10]2[CH:11]=[CH:12][C:7]([C:6]([OH:23])=[O:5])=[C:8]([N+:20]([O-:22])=[O:21])[CH:9]=2)[CH2:14][CH2:15]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 45791321tert-Butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate

생성물 1

HCID 667368904-(4-Methylpiperazin-1-yl)-2-nitrobenzoic acid hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 4-(4-methyl-piperazin-1-yl)-2-nitro-benzoic acid tert-butyl ester (16.4 g, 51 mmol) and 37% HCl (100 mL) in 1,4-dioxane (200 mL) was stirred at room temperature for 4 hours. The resulting solid was filtered, washed thoroughly with 1,4-dioxane and dried under vacuum at 45° C. The title compound was obtained as a pale yellow solid (13.45 g, 87.5% yield), and it was used in the next step without any further purification.

후처리

  1. filtrationThe resulting solid was filtered
  2. washwashed thoroughly with 1,4-dioxane
  3. customdried under vacuum at 45° C

출처 및 근거

ORD 기록
ord-73c84527a88e4d3ba0cce6b3659a94d6
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102662B2

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