Sodium borohydride → 4-Chloro-furo[3,4-c]quinolin-1(3H)-one

HRID 5130노트

반응식

HRID 5130 반응식
[Cl:1][C:2]1[C:11]2[C:12](=[O:16])[O:13][C:14](=[O:15])[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.[BH4-].[Na+]>O1CCCC1>[Cl:1][C:2]1[C:11]2[C:12](=[O:16])[O:13][CH2:14][C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.[Cl:1][C:2]1[C:11]2[CH2:12][O:13][C:14](=[O:15])[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 541042384-Chloro-furo[3,4-c]quinoline-1,3-dione

생성물 2

HCID 112067664-Chloro-furo[3,4-c]quinolin-1(3H)-oneHCID 57030353HCID 57030353, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a well stirred mixture of 4-Chloro-furo[3,4-c]quinoline-1,3-dione (1.9 g) in tetrahydrofuran (10 mL) was added sodium borohydride (400 mg) at 0° C. and stirring was continued for 2 h. The reaction was then quenched with excess 6N HCl and water, and concentrated in vacuo to afford 4-Chloro-furo[3,4-c]quinolin-3(1H)-one as a pink solid along with a small quantity of 4-Chloro-furo[3,4-c]quinolin-1(3H)-one which could be isolated by column chromatography on silica gel.

후처리

  1. stirringstirring
  2. customThe reaction was then quenched with excess 6N HCl and water
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-fdab9219ef3743deb64f5cb01f5301ba
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05243049

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