Ammonia → 3-Methyl-8-quinolinamine

HRID 513384

반응식

HRID 513384 반응식
[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2O.S([O-])([O-])=O.[NH4+:17].[NH4+].N>O>[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2[NH2:17]

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 25041Ammonium SulfiteHCID 43322813-Methylquinolin-8-ol2회

생성물 1

HCID 157837943-Methyl-8-quinolinamine수율 91.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

3-methylquinolin-8-ol (Intermediate 30) (150 mg, 0.9 mmol) and ammonium sulphite (250 mg, 1.8 mmol) were added to aqueous ammonia (3 ml) and heated for 48 h. After cooling, water was added and the mixture was extracted with DCM. The organic phase was dried (Na2SO4) and concentrated in vacuo to give the title compound (130 mg, 86%).

후처리

  1. temperatureheated for 48 h
  2. temperatureAfter cooling
  3. extractionthe mixture was extracted with DCM
  4. dry with materialThe organic phase was dried (Na2SO4)
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-deb45c358e1b499eb3e02cc0c03b2144
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

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