Ammonia → 3-Methyl-8-quinolinamine
반응식
[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2O.S([O-])([O-])=O.[NH4+:17].[NH4+].N>O>[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2[NH2:17]참가 물질
5
실험 절차
3-methylquinolin-8-ol (Intermediate 30) (150 mg, 0.9 mmol) and ammonium sulphite (250 mg, 1.8 mmol) were added to aqueous ammonia (3 ml) and heated for 48 h. After cooling, water was added and the mixture was extracted with DCM. The organic phase was dried (Na2SO4) and concentrated in vacuo to give the title compound (130 mg, 86%).
후처리
- temperatureheated for 48 h
- temperatureAfter cooling
- extractionthe mixture was extracted with DCM
- dry with materialThe organic phase was dried (Na2SO4)
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-deb45c358e1b499eb3e02cc0c03b2144
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09102688B2
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