Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
8-Aminoquinoline → 3-(Quinolin-8-ylsulfamoyl)-benzoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 8-Aminoquinoline | HCID 11359 | — |
| 반응물 | Benzoic acid, 3-(chlorosulfonyl)-, methyl ester | HCID 113339 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 생성물 | 3-(Quinolin-8-ylsulfamoyl)-benzoic acid methyl ester | HCID 31702993 | 64% |
반응 단계
In the similar fashion using route 14 general procedure 27, 8-aminoquinoline (100 mg, 0.69 mmol), methyl 3-chlorosulfonylbenzoate (160 mg, 0.69 mmol) and DMAP (cat.) gave the title compound (150 mg, 64%) after purification by column chromatography with DCM as the eluent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09102688B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-8dee330c2dd447c49a029927665986ad |
| 출처 메모 | uspto-grants-2015_08 |