8-Aminoquinoline → 4-chloro-2-fluoro-N-(quinolin-8-yl)benzene-1-sulfonamide
반응식
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[C:15]([F:23])[CH:14]=1>CN(C1C=CN=CC=1)C>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([S:19]([NH:1][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]3[C:11]=2[N:10]=[CH:9][CH:8]=[CH:7]3)(=[O:20])=[O:21])=[C:15]([F:23])[CH:14]=1참가 물질
4
실험 절차
In the similar fashion using route 14 general procedure 27, 8-aminoquinoline (100 mg, 0.69 mmol), 4-chloro-2-fluorobenzenesulfonyl chloride (200 mg, 0.83 mmol) and DMAP (cat.) gave the title compound (190 mg, 82%) after purification by column chromatography with DCM as the eluent.
출처 및 근거
- ORD 기록
- ord-5b4fb98268aa45a99e79739ed819b0cd
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09102688B2
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