Pyridine → HCID 60164191, 화합물
반응식
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[S:7](Cl)(=[O:9])=[O:8].[N:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>CN(C1C=CN=CC=1)C.C(Cl)Cl>[N:11]1[C:16]2[C:15](=[CH:15][CH:14]=[CH:13][C:12]=2[NH:11][S:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)(=[O:9])=[O:8])[CH:14]=[CH:13][CH:12]=1참가 물질
5
실험 절차
In a similar fashion using route 18 general procedure 27, 8-aminoqunoline (300 mg, 2.08 mmol), pyrazine-2-sulfonyl chloride 443 (482 mg, 2.7 mmol), pyridine (3 ml), DMAP (cat.) and DCM (2 ml) gave the title compound (102 mg, 13%) after purification by column chromatography with n-hexane/EtOAc (90:10) as the eluent.
출처 및 근거
- ORD 기록
- ord-89eb4741f5ea47399f36517aaea0d486
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09102688B2
반응 노트
불러오는 중…