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Pyridine → 6-Trifluoromethyl-pyridine-3-sulfonic acid (6-trifluoromethoxy-quinolin-8-yl)-amide

HRID 513492
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인쇄 미리보기

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HRID 513492 반응식
[F:1][C:2]([F:16])([F:15])[O:3][C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([NH2:14])[CH:13]=1)[N:10]=[CH:9][CH:8]=[CH:7]2.[F:17][C:18]([F:30])([F:29])[C:19]1[N:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1.N1C=CC=CC=1>CN(C1C=CN=CC=1)C.C(Cl)Cl>[F:16][C:2]([F:1])([F:15])[O:3][C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([NH:14][S:25]([C:22]3[CH:23]=[N:24][C:19]([C:18]([F:30])([F:17])[F:29])=[CH:20][CH:21]=3)(=[O:27])=[O:26])[CH:13]=1)[N:10]=[CH:9][CH:8]=[CH:7]2
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 1049PyridineHCID 455943116-(Trifluoromethyl)pyridine-3-sulfonyl chlorideHCID 681830016-(Trifluoromethoxy)quinolin-8-amine2회

생성물 1

HCID 601641926-Trifluoromethyl-pyridine-3-sulfonic acid (6-trifluoromethoxy-quinolin-8-yl)-amide수율 42.9%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine
촉매
HCID 6344Dichloromethane용매

실험 절차

In a similar fashion using route 14 general procedure 27, 6-trifluoromethoxy-quinolin-8-ylamine (Intermediate 46) (75 mg, 0.32 mmol), 6-(trifluoromethyl)pyridine-3-sulfonyl chloride (96 mg, 0.39 mmol), DMAP (cat.), pyridine (0.05 ml, 0.65 mmol) and DCM (2 ml) gave the title compound (60 mg, 42%) after purification by column chromatography with n-hexane/EtOAc (90:10) as the eluent.

출처 및 근거

ORD 기록
ord-0b006ee69deb445fafad0e141b5a9790
출처 데이터셋
uspto-grants-2015_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09102688B2

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