홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Pyridine → 6-Trifluoromethyl-pyridine-3-sulfonic acid (5-trifluoromethyl-quinolin-8-yl)-amide

HRID 513493
노트
인쇄 미리보기

반응식

HRID 513493 반응식
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:12]=[CH:11][C:10]([NH2:13])=[C:9]2[C:4]=1[CH:5]=[CH:6][CH:7]=[N:8]2.[F:16][C:17]([F:29])([F:28])[C:18]1[N:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1.N1C=CC=CC=1>CN(C1C=CN=CC=1)C.C(Cl)Cl>[F:15][C:2]([F:1])([F:14])[C:3]1[CH:12]=[CH:11][C:10]([NH:13][S:24]([C:21]2[CH:22]=[N:23][C:18]([C:17]([F:29])([F:16])[F:28])=[CH:19][CH:20]=2)(=[O:26])=[O:25])=[C:9]2[C:4]=1[CH:5]=[CH:6][CH:7]=[N:8]2
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 1049PyridineHCID 103531188-Quinolinamine, 5-(trifluoromethyl)-2회HCID 455943116-(Trifluoromethyl)pyridine-3-sulfonyl chloride

생성물 1

HCID 601641936-Trifluoromethyl-pyridine-3-sulfonic acid (5-trifluoromethyl-quinolin-8-yl)-amide수율 13%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매
HCID 6344Dichloromethane용매

실험 절차

In a similar fashion using route 14 general procedure 27, 5-trifluoromethyl-quinolin-8-ylamine (Intermediate 45) (100 mg, 0.47 mmol), 6-(trifluoromethyl)pyridine-3-sulfonyl chloride (138 mg, 0.56 mmol), pyridine (0.08 ml, 0.94 mmol), DMAP (cat.) and DCM (5 ml) gave the title compound (25 mg, 13%) after purification by column chromatography with n-hexane/DCM (50:50) as the eluent.

출처 및 근거

ORD 기록
ord-a6758c5aaf494fababd9e0ff641c2435
출처 데이터셋
uspto-grants-2015_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09102688B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차출처 및 근거반응 노트