Pyridine → 2-Nitro-N-quinoxalin-5-yl-benzenesulfonamide

HRID 513512

반응식

HRID 513512 반응식
[N:1]1[C:10]2[C:5](=[C:6]([NH2:11])[CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][CH:2]=1.[N+:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[S:21](Cl)(=[O:23])=[O:22])([O-:14])=[O:13].N1C=CC=CC=1>C(Cl)Cl>[N+:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[S:21]([NH:11][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:5]=1[N:4]=[CH:3][CH:2]=[N:1]2)(=[O:23])=[O:22])([O-:14])=[O:13]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 155402-Nitrobenzenesulfonyl chlorideHCID 854945-Aminoquinoxaline2회

생성물 1

HCID 681833542-Nitro-N-quinoxalin-5-yl-benzenesulfonamide수율 56%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In a similar fashion using route 14 general procedure 26, quinoxalin-5-ylamine (Intermediate 482) (540 mg, 3.7 mmol), 2-nitro-benzenesulfonyl chloride (986 mg, 4.46 mmol), pyridine (0.9 ml, 7.44 mmol) and DCM (10 ml) gave the title compound (679 mg, 56%) after purification by column chromatography with DCM as the eluent.

출처 및 근거

ORD 기록
ord-7512a3a30b974f92835ebd98f46493a2
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

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