Benzyl mercaptan → 2-(Benzylthio)-3-nitropyridine

HRID 513714

반응식

HRID 513714 반응식
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.C([O-])([O-])=O.[Na+].[Na+].[CH2:17]([SH:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CCO>[CH2:17]([S:24][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

5

반응물 3

HCID 7509Benzyl mercaptanHCID 10340Sodium CarbonateHCID 796132-Chloro-3-nitropyridine

생성물 1

HCID 5073002-(Benzylthio)-3-nitropyridine수율 96%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In a similar fashion using route 38 general procedure 92, 2-chloro-3-nitro-pyridine(2 g, 12.7 mmol), Na2CO3 (1.75 g, 16.6 mmol), benzylmercaptan (1.87 g, 15.1 mmol) and EtOH (20 ml) at 90° C. for 4 h gave the title compound (3 g, 96%) which was used in the next step without further purification. The structure was confirmed by 1H NMR.

후처리

  1. customat 90° C.
  2. customfor 4 h

출처 및 근거

ORD 기록
ord-29ad9f09c69c4c328a084f911264c85c
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

연결된 노트

불러오는 중…