4-Chloro-8-nitroquinazoline → HCID 11462514, 화합물

HRID 513743

반응식

HRID 513743 반응식
O.[C:2]1([CH3:13])[CH:7]=[CH:6][C:5]([S:8]([NH:11][NH2:12])(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl[C:15]1[C:24]2[C:19](=[C:20]([N+:25]([O-:27])=[O:26])[CH:21]=[CH:22][CH:23]=2)[N:18]=[CH:17][N:16]=1>C(Cl)Cl>[CH3:13][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][NH:12][C:15]2[C:24]3[C:19](=[C:20]([N+:25]([O-:27])=[O:26])[CH:21]=[CH:22][CH:23]=3)[N:18]=[CH:17][N:16]=2)(=[O:9])=[O:10])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 114584714-Chloro-8-nitroquinazolineHCID 86669768HCID 86669768, 화합물

생성물 1

HCID 11462514HCID 11462514, 화합물수율 95%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

p-Toluene sulphonyl hydrazine hydrate (390 mg, 2.1 mmol) was added to a solution of 4-chloro-8-nitro-quinazoline 477 (400 mg, 1.91 mmol) in DCM at (10 ml) and the mixture was stirred at room temperature for 24 h. The mixture was concentrated in vacuo and washed with Et20 to give the title compound (650 mg, 95%).

후처리

  1. concentrationThe mixture was concentrated in vacuo
  2. washwashed with Et20

출처 및 근거

ORD 기록
ord-df26422ddfb343fabb844c4eb5bb9369
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

연결된 노트

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