m-Chloroperbenzoic acid → 1-Oxo-1lambda~5~-1,5-naphthyridine

HRID 513748

반응식

HRID 513748 반응식
C1C=C(Cl)C=C(C(OO)=[O:9])C=1.[N:12]1[C:21]2[C:16](=[N:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1>C(Cl)Cl>[N+:12]1([O-:9])[C:21]2[C:16](=[N:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 1360701,5-Naphthyridine

생성물 1

HCID 3392321-Oxo-1lambda~5~-1,5-naphthyridine수율 84.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

m-CPBA (1.2 g, 6.91 mmol) was added in 3 portions (after every 3 h) to a solution of 1,5-naphthyridine (1.0 g, 7.68 mmol) in dry DCM (60 ml). After completion of the reaction, the mixture was concentrated in vacuo. The crude residue was purified by column chromatography with DCM/MeOH (98:2) as the eluent to get title compound (0.85 g, 76%).

후처리

  1. customAfter completion of the reaction
  2. concentrationthe mixture was concentrated in vacuo
  3. customThe crude residue was purified by column chromatography with DCM/MeOH (98:2) as the eluent

출처 및 근거

ORD 기록
ord-961c72abf7164039bb788d5de36401b8
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

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