Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
m-Chloroperbenzoic acid → 1-Oxo-1lambda~5~-1,5-naphthyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 반응물 | 1,5-Naphthyridine | HCID 136070 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-Oxo-1lambda~5~-1,5-naphthyridine | HCID 339232 | 84.2% |
반응 단계
m-CPBA (1.2 g, 6.91 mmol) was added in 3 portions (after every 3 h) to a solution of 1,5-naphthyridine (1.0 g, 7.68 mmol) in dry DCM (60 ml). After completion of the reaction, the mixture was concentrated in vacuo. The crude residue was purified by column chromatography with DCM/MeOH (98:2) as the eluent to get title compound (0.85 g, 76%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09102688B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-961c72abf7164039bb788d5de36401b8 |
| 출처 메모 | uspto-grants-2015_08 |