反应详情

m-CPBA (1.2 g, 6.91 mmol) was added in 3 portions (after every 3 h) to a solution of 1,5-naphthyridine (1.0 g, 7.68 mmol) in dry DCM (60 ml). After completion of the reaction, the mixture was concentrated in vacuo. The crude residue was purified by column chromatography with DCM/MeOH (98:2) as the eluent to get title compound (0.85 g, 76%).

1. customAfter completion of the reaction
2. concentrationthe mixture was concentrated in vacuo
3. customThe crude residue was purified by column chromatography with DCM/MeOH (98:2) as the eluent