Diisopropylethylamine → HCID 68005840, 화합물

HRID 513868노트

반응식

HRID 513868 반응식
Cl[CH:2]([O:8][CH3:9])[CH2:3][Si:4]([CH3:7])([CH3:6])[CH3:5].[Br:10][C:11]1[CH:12]=[CH:13][C:14]2[N:18]=[C:17]([CH:19]([F:21])[F:20])[NH:16][C:15]=2[CH:22]=1.C(N(CC)C(C)C)(C)C>ClCCl>[Br:10][C:11]1[CH:12]=[CH:13][C:14]2[N:18]=[C:17]([CH:19]([F:20])[F:21])[N:16]([CH2:9][O:8][CH2:2][CH2:3][Si:4]([CH3:7])([CH3:6])[CH3:5])[C:15]=2[CH:22]=1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 647235395-bromo-2-(difluoromethyl)-1H-1,3-benzodiazoleHCID 87805942(2-Chloro-methoxy-ethyl)-trimethyl-silane

생성물 1

HCID 68005840HCID 68005840, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(2-Chloro-methoxy-ethyl)-trimethyl-silane (1.1 ml, 6.4 mmol, 1.5 eq.) was added to an anhydrous dichloromethane solution (22 ml) of 6-bromo-2-difluoromethyl-1H-benzimidazol (1.0 g, 4.27 mmol) and N,N-diisopropyl ethyl amine (1.9 ml, 10.6 mmol, 2.5 eq.). This was stirred at room temperature for 18 hours. The reaction mixture was concentrated. The residue obtained by concentration under reduced pressure was purified by silica gel column chromatography. Thus, 6-bromo-2-difluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzimidazole was obtained as a yellow solid (1.37 g, 85%).

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customThe residue obtained by concentration under reduced pressure
  3. customwas purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-1fb922418c6041e684a285a103abca4a
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102692B2

반응 노트

불러오는 중…