3-Butyn-2-amine, 2-methyl- → (S)-2-(7-(3-amino-3-methylbut-1-ynyl)-1-(4-chlorophenyl)-3-methylnaphthalen-2-yl)-2-tert-butoxyacetic acid

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][C:14](OS(C(F)(F)F)(=O)=O)=[CH:15][CH:16]=3)[CH:11]=[C:10]([CH3:26])[C:9]=2[C@H:27]([OH:33])[C:28]([O:30]CC)=[O:29])=[CH:4][CH:3]=1.[BH4-].[Na+].BrC1C=[C:45]2[C:40]([CH:41]=C(C)C(C(=O)C(OCC)=O)=C2C2C=CC(Cl)=CC=2)=[CH:39]C=1.[CH3:62][C:63]([NH2:67])([C:65]#[CH:66])[CH3:64]>>[NH2:67][C:63]([CH3:64])([CH3:62])[C:65]#[C:66][C:15]1[CH:16]=[C:17]2[C:12]([CH:11]=[C:10]([CH3:26])[C:9]([C@H:27]([O:33][C:40]([CH3:45])([CH3:41])[CH3:39])[C:28]([OH:30])=[O:29])=[C:8]2[C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)=[CH:13][CH:14]=1