Methanol → 1-Chloro-5-fluoro-2-methoxy-4-nitrobenzene
반응식
C(=O)([O-])OCC[C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([F:14])=[CH:7][C:6]=1[Cl:15].[C:18](=O)([O-])[O-:19].[Cs+].[Cs+].IC.CO>CN(C)C=O.O>[Cl:15][C:6]1[CH:7]=[C:8]([F:14])[C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:5]=1[O:19][CH3:18]참가 물질
7
실험 절차
A solution of 15.0 g of (2-chloro-4-fluoro-5-nitrophenyl)-ethyl carbonate in 100 ml of dimethyl formamide was treated with 18.6 g of cesium carbonate, 7.1 ml of iodomethane and 7 ml of methanol and stirred overnight at room temperature. The reaction mixture was poured into water and extracted twice with ether. The extracts were washed twice with water and then with brine, dried over magnesium sulfate and concentrated to afford 11.4 g of the subtitle compound. mp. 69-70° C. Ex. 57, C.
후처리
- extractionextracted twice with ether
- washThe extracts were washed twice with water
- dry with materialwith brine, dried over magnesium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-faa14b06cf2b4e0d9eae0409f8197195
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06713645B1
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