Benzyl Bromide → HCID 58083510, 화합물

HRID 514454

반응식

HRID 514454 반응식
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Cl:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:17][OH:18])=[C:14]([OH:16])[CH:15]=1.[OH-].[Na+]>C(O)C>[Cl:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:17][OH:18])=[C:14]([O:16][CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH:15]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 14798Sodium HydroxideHCID 3271485-Chloro-2-(hydroxymethyl)phenol

생성물 1

HCID 58083510HCID 58083510, 화합물수율 28%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

(Bromomethyl)benzene (323 mg, 1.89 mmol) was added to a mixture of 5-chloro-2-(hydroxymethyl)phenol (300 mg, 1.89 mmol, PREPARATION 7) and NaOH (1.1 mL, 2M in water) in ethanol (5 mL) at r.t. slowly. The reaction mixture was stirred overnight. Poured into ice water, and extracted with ethyl acetate twice, and washed the organic phase with water twice, brine and dried with anhydrous Na2SO4. The solvents were removed and the residue purified by silica gel chromatograph to give 120 mg of the title compound (28%).

후처리

  1. extractionextracted with ethyl acetate twice
  2. washwashed the organic phase with water twice
  3. dry with materialbrine and dried with anhydrous Na2SO4
  4. customThe solvents were removed
  5. customthe residue purified by silica gel chromatograph

출처 및 근거

ORD 기록
ord-bd2a2b399d87489caf3a31043675f9b3
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09107916B2

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